Tabela 3. Unakrsna reaktivnost glavnih metabolita Tacrolimusa

Tabela  3. Unakrsna reaktivnost glavnih metabolita Tacrolimusa

Metabolit

Bioaktivnost  % 5, 6

Koncentracija

srodnika do roditelja (%)

Seimens
ACMIA

Microgenics
CEDIA

Syva
EMIT

Abbott
MEIA

M I
13-O-demethyl

6

6

14.8% @
50 ng/mL

37.7% @
20 ng/mL

10.4% @
100 ng/mL

8% @
10 ng/mL

M II
31-O-demethyl

100

15

2.7% @
50 ng/mL

<AS @
20 ng/mL

1.6% @
100 ng/mL

94% @
10 ng/mL

M III
15-O-demethyl

0

6

1.0% @
50 ng/mL

<AS @
20 ng/mL

2.2% @
100 ng/mL

45% @
10 ng/mL

M IV
12 hydroxyl

3.5

NS

18.0% @
50 ng/mL

NS

21.1% @
100 ng/mL

9% @
10 ng/mL

M V
15, 31-O-didemethyl

0

NS

0.5% @
50 ng/mL

NS

2.5% @
100 ng/mL

NS

Skraćenice : AS, analitička senzitivnost; NS, nije navedeno; ACMIA, affinity column-mediated immunoassay; CEDIA, cloned-enzyme donor immunoassay; EMIT, enzyme-multiplied immunoassay; and MEIA, microparticle enzyme immunoassay